DJ Khaled said the news about Bryant's death was "devastating." He took part in a tribute to the late Nipsey Hussle that also included John Legend, Meek Mill, Kirk Franklin, Roddy Ricch and YG. They performed "Letter to Nipsey" and "Higher."
At the end of the performance, each performer turned around and pointed toward a screen with a picture of Hussle and Bryant. The tribute prompted a standing ovation that lasted for more than a minute.
"Long live Nip. Long live Kobe Bryant. Long live Gianna. The marathon continues," Khaled said.
Tyler, the Creator said he went through different emotions.
"The news was heavy, especially being in LA and being near the Staples Center within a short period of time between him and Nipsey," he said backstage after winning best rap album. Hussle, who was known for being a huge Lakers fan, was shot and killed 10 months ago in Los Angeles.
"If you're from Los Angeles, depending on which sector you're in, that (expletive) is really heavy," the rapper continued. "We took an L tonight. Rest in peace to Kobe. We also took a win just being from Los Angeles. It's mixed emotions."
Billy Ray Cyrus had No. 24, Bryant's number, on his guitar, and Lil Nas X had a Bryant jersey draped over a chair at the beginning of their performance of "Old Town Road."
Run-DMC member Joseph "Run" Simmons held up a white Bryant Jersey during the group's performance of "Walk This Way" with Aerosmith.
Smokey Robinson choked up on camera as he spoke of Bryant, whom he called a friend.
"As a dad myself, to think that his daughter was there with him and there was nothing he could do for her," he said. "My god."